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Screening for 300+ Conditions and Medication Interactions. New Conditions Added Annually.

FORESITE 360 is built to be at the forefront of children’s preventative care providing genetic diagnosis for health conditions and medication adherence. We continue to expand our list of conditions screened for your child’s initial test, or annual reanalysis. Please see our condition categories, and email us any questions

what we test for (2)

Genes and Conditions

FORESITE 360 is the most comprehensive genetic test for children. Whole genome sequencing with reporting on over 300 conditions plus response to childhood medications and annual reanalysis gives the best opportunity for early detection and mitigation of disease.


Metabolism is the process your body uses to get or make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system break the food parts down into sugars and acids, your body's fuel. Your body can use this fuel right away, or it can store the energy in your body tissues, such as your liver, muscles, and body fat.

A metabolic disorder occurs when abnormal chemical reactions in your body disrupt this process. When this happens, you might have too much of some substances or too little of other ones that you need to stay healthy. There are different groups of disorders. Some affect the breakdown of amino acids, carbohydrates, or lipids. Another group, mitochondrial diseases, affects the parts of the cells that produce the energy.

You can develop a metabolic disorder when some organs, such as your liver or pancreas, become diseased or do not function normally. Diabetes is an example.


The brain, spinal cord, and nerves make up the nervous system. Together they control all the workings of the body. When something goes wrong with a part of your nervous system, you can have trouble moving, speaking, swallowing, breathing, or learning. You can also have problems with your memory, senses, or mood.

There are more than 600 neurologic diseases. Major types include:


The endocrine system is a network of glands that produce and release hormones that help control many important body functions, including the body's ability to change calories into energy that powers cells and organs. The endocrine system influences how your heart beats, how your bones and tissues grow, even your ability to make a baby. It plays a vital role in whether or not you develop diabetes, thyroid disease, growth disorders, sexual dysfunction, and a host of other hormone-related disorders.


Cardiovascular diseases (CVDs) affect your heart and blood vessels. Almost half of all adults in the U.S. have at least one form of heart disease. You may make lifestyle changes to manage cardiovascular disease or your healthcare provider may prescribe medications. The sooner you detect cardiovascular disease, the easier it is to treat.

Pediatric Oncology

Childhood or pediatric cancer describes a group of cancers that affect children (infants to age 14) and teenagers (age 15 to age 19). Childhood cancer isn’t common, but when it happens, it changes the lives of children with the condition, their parents and caregivers.

Thanks to newer treatments tailored to their needs, more than 80% of children and teenagers were alive five years after a cancer diagnosis. But childhood cancer treatment casts a long shadow. Survivors of childhood cancer have increased risk of second cancers and other medical conditions.


Immunodeficiency disorders may affect any part of the immune system. Most often, these conditions occur when special white blood cells called T or B lymphocytes (or both) do not function normally or your body does not produce enough antibodies.

Inherited immunodeficiency disorders that affect B cells include:

  • Hypogammaglobulinemia, which usually leads to respiratory and gastrointestinal infections
  • Agammaglobulinemia, which results in severe infections early in life, and is often deadly

Inherited immunodeficiency disorders that affect T cells may cause repeated Candida (yeast) infections. Inherited combined immunodeficiency affects both T cells and B cells. It may be deadly within the first year of life if it isn't treated early.

People are said to be immunosuppressed when they have an immunodeficiency disorder due to medicines that weaken the immune system. Examples include:

  • Corticosteroids 
  • Drugs used to treat health problems such as rheumatoid arthritis, inflammatory bowel disease, and certain skin conditions
  • Chemotherapy given to treat cancer

Skin diseases are conditions that affect your skin. These diseases may cause rashes, inflammation, itchiness or other skin changes. Some skin conditions may be genetic, while lifestyle factors may cause others. Skin disease treatment may include medications, creams or ointments, or lifestyle changes.

Hearing Loss

Hearing loss is the impairment of auditory function, which can have significant long-term consequences on social and language development. It can develop prelingually (before the acquisition of speech/language) or post-lingually (after the acquisition of speech/language). Genetic hearing loss can have significant impacts on social development. They present prelingually or postlingually and can be inherited via many mechanisms. To avoid the long-term consequences of this condition, it must be promptly diagnosed and treated. This activity reviews the evaluation and treatment of genetic hearing loss and highlights the role of the interprofessional team in evaluating and treating patients with this condition.


There are many types of liver disease. Some of the most common types are treatable with diet and lifestyle changes, while others may require lifelong medication to manage. If you begin treatment early enough, you can often prevent permanent damage. But you may not have symptoms in the early stages. Late-stage liver disease is more complicated to treat.

Vision Loss

There are hundreds of different eye diseases and vision problems. Some have no cure, but many others are treatable.

Eye conditions commonly seen in children include:

  • Amblyopia: Amblyopia (also called “lazy eye”) happens when your child’s brain and one eye aren’t working together properly and the brain favors the other better-seeing eye. They'll have reduced vision in the non-favored eye. This is the most common cause of vision impairment in children.
  • Strabismus: Strabismus is a lack of coordination between your child’s eyes, which causes the eyes to cross or turn out. Your child’s eyes don’t focus together on a single image at the same time. This can cause reduced 3D vision and/or the brain may favor one eye over the other, which can cause loss of vision in the non-favored eye (amblyopia, see above).

You have two kidneys, each about the size of your fist. They are near the middle of your back, just below the rib cage. Inside each kidney there are about a million tiny structures called nephrons. They filter your blood. They remove wastes and extra water, which become urine. The urine flows through tubes called ureters. It goes to your bladder, which stores the urine until you go to the bathroom.

Most kidney diseases attack the nephrons. This damage may leave kidneys unable to remove wastes. Causes can include genetic problems, injuries, or medicines. You have a higher risk of kidney disease if you have diabetes, high blood pressure, or a close family member with kidney disease. Chronic kidney disease damages the nephrons slowly over several years.


Musculoskeletal health refers to the performance of the locomotor system, comprising intact muscles, bones, joints and adjacent connective tissues. Musculoskeletal impairments comprise more than 150 different diseases/conditions that affect the system and are characterized by impairments in the muscles, bones, joints and adjacent connective tissues leading to temporary or lifelong limitations in functioning and participation. Musculoskeletal conditions are typically characterized by pain (often persistent) and limitations in mobility and dexterity, reducing people’s ability to work and participate in society. Pain experienced in musculoskeletal structures is the most common form of non-cancer pain.

Musculoskeletal conditions are relevant across the life-course – from childhood to older age. They range from those conditions that arise suddenly and are short-lived (such as fractures, sprains and strains, associated with pain and limitations in functioning) though to long-term conditions such as chronic primary low back pain and osteoarthritis.


Gastrointestinal diseases affect your gastrointestinal (GI) tract, from mouth to anus. There are two types: functional and structural. Some examples include colitis, food poisoning, lactose intolerance and diarrhea.

Congenital Abnormalities

Congenital disorders can be defined as structural or functional anomalies that occur during intrauterine life. Also called birth defects, congenital anomalies or congenital malformations, these conditions develop prenatally and may be identified before or at birth, or later in life.


A type of disease that affects the lungs and other parts of the respiratory system. Pulmonary diseases may be caused by infection, by smoking tobacco, or by breathing in secondhand tobacco smoke, radon, asbestos, or other forms of air pollution. Pulmonary diseases include asthma, chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, pneumonia, and lung cancer. Also called lung disorder and respiratory disease.

Medications (PGx)

Pharmacogenomics is an important example of the field of precision medicine, which aims to tailor medical treatment to each person or to a group of people. Pharmacogenomics looks at how your DNA affects the way you respond to drugs. In some cases, your DNA can affect whether you have a bad reaction to a drug or whether a drug helps you or has no effect. Pharmacogenomics can improve your health by helping you know ahead of time whether a drug is likely to benefit you and be safe for you to take. Knowing this information can help your doctor find medicine that will work best for you.


FORESITE 360 reports on Anesthesiology, Cardiovascular, Gastroenterology, Immunology, Infection Disease, Neurology, Oncology, Pain Managment, Psychiatry and Other Medications.

Parent's Guide eBook

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